Transition to non-animal research

VIVISECTION

Akhtar 2015 – The Flaws and Human Harms of Animal experiments

Akhtar et al. 2009 – Animal studies in spinal cord injury a systematic review of methylprednisolone

Archibald 2011- Corresp – Safety of medicine and the use of animals in research

Bailey 2009 – An examination of chimpanzee use in human cancer research

Bailey 2013 – An Analysis of the Use of Dogs in Predicting Human Toxicology and Drug Safety

Bailey and Taylor 2016 – Non-human Primates in Neuroscience Research – The Case Against its Scientific Necessity

Bailey et al 2014 – An Analysis of the Use of Animal Models in Predicting Human Toxicology and Drug Safety

Bailey et al 2015 – Predicting Human Drug Toxicity and Safety via Animal Tests – Can Any One Species Predict Drug Toxicity

Bailey et al. 2013 An Analysis of the Use of Dogs in Predicting Human Toxicology and Drug Safety

Balcombe et al. 2004 – Laboratory routine causes animal stress

Balls 2004 – Are Animal Tests Inherently Valid

Balls 2012 -The Conflict over Animal Experimentation – Is the Field of Battle Changing

Balls 2016 – Scientific Issues Raised by the Use of Dogs as Laboratory animals

Barbaric 2007 – Appearances can be deceiving – phenotypes of KO mice

Behan 2010 – Futility of the autoimmune orthodoxy in multiple sclerosis research

Bhogal and Combes 2006 -The relevance of genetically altered mouse models of human disease

Bunner et al. 2014 – Knockout mouse models of insulin signaling – relevance past and future

Carvalho et al 2016 – Contribution of animal models to contemporary understanding of Attention Deficit Hyperactivity Disorder

Cavanaugh et al 2014 – Animal Models of Alzheimer Disease – historical pitfalls and a path forward

Chandrasekera, Pippin – 2013 – Of Rodents and Men Species-Specific Glucose Regulation and Type 2 Diabetes Research

Davis 2008 – A Prescription for Human Immunology

DiCarlo 1984 – Carcinogenesis Bioassay Data – Correlation by Species and Sex

Drake – 2013 – Of mice and men what rodent models don’t tell us

Gentile et al. 2014 – A Better Understanding of Why Murine Models of trauma Do Not Recapitulate the Human Syndrome

Gharib and Rechavi 2011 – When orthologs diverge between human and mouse

Glazko et al 2005 – Eighty percent of proteins are different between humans and chimpanzees

Godlee 2014 – How predictive and productive is animal research

Greek 2014 – A Discussion of the Role of Complex Evolved Systems in the Development of Invasive Cardiovascular Interventions

Greek and Menache 2013 Systematic Reviews of Animal Models Methodology vs epistemology

Greek et al 2012 – Animal models in an age of personalized medicine

Greek et al 2012 -The Nuremberg Code subverts human health and safety by requiring animal modeling

Hartung – 2008 – Food for thought… on animal tests

Hartung 2009 – Per aspirin ad astra..

Hartung 2009 – toxicology for the 21 century

Khanna and Burrows 2011 – Human immunology – a case for the ascent of non-furry immunology

Koufaris 2012 – Are differences in microRNA regulation implicated in speciesdependent

Laurijssens, Aujard, Rahman – 2013 – Animal models of Alzheimer’s disease and drug development

Leist and Hartung 2013 – Inflammatory findings on species extrapolations – humans are definitely no 70-kg mice

Lindl and Voekl 2011 -No clinical relevance of approved animal experiments after seventeen years

Lynch – 2009 – Use with caution developmental systems divergence and potential pitfalls of animal models

Mak et al 2014 – Lost in translation – animal models and clinical trials in cancer treatments

Matthews 2008 – Medical progress depends on animal models – isn’t it

Menache and Nastrucci 2012 – Reach -animal-testing-and-the-precautionary-principle

Napoli_et_al-2016 – Comparative Analysis of Human and Rodent Brain Primary Neuronal Culture Spontaneous Activity Using Micro-Electrode Array

O Behan 2010 – Futility of the autoimmune orthodoxy in multiple sclerosis research

Odom et al 2007-Tissue specific transcriptional regulation has diverged significantly between human and mouse

Pamies, Hartung, Hogberg – 2014 – Minireview Biological and medical applications of a brain-on-a-chip

Perel et al 2007 – Comparison of treatment effects between animal experiments and clinical trials systematic review

Pistollato et al. 2015 – Alzheimer disease research in the 21st century – past and current failures, new perspectives and funding priorities

Pound 2014 – Is animal research sufficiently evidence based to be a cornerstone of biomedical research

Pound et al 2004 -Where is the evidence that animal research benefits humans

Schnerch et al 2010 – Distinguishing between mouse and human pluripotent stem cell regulation – the best laid plans of mice and men

Sena et al 2010 – Publication Bias in Reports of Animal Stroke Studies Leads to Major Overstatement of Efficacy

Seok et al 2013 – Genomic responses in mouse models poorly mimic human inflammatory diseases

Shanks et al. 2009 – Are animal models predictive for humans

Siram 2005 -Experimental Allergic Encephalomyelitis – a misleading model of multiple sclerosis

Stingl et al. 2009 – 20 years of hypertension research using genetically modified animals no clinically promising approaches in sight

Sucking 2008 – Too faith in models clouds judgement

The turkish journal of gastroenterology – letter from the editor

van der worp et al 2010 – Can Animal Models of Disease Reliably Inform Human studies

van der Worp, Macleod – 2011 – Preclinical studies of human disease time to take methodological quality seriously

Van Meer 2012 – The ability of animal studies to detect serious post marketing adverse events is limited

ALTERNATIVE METHODS

Abbott 2005 -More than a cosmetic change

Archibald et al 2015 – Barriers to the Uptake of Human based Test Methods and How to Overcome Them

Bailey et al 2005 -The future of teratology research is in vitro

Ball et al. 2012 -The Human Brain Online An Open Resource for Advancing Brain Research

Balls 2013 – The wisdom of replacement

Brown – 2015 – The Cost of Standing Strong for Replacement

Brunner et al 2010 -Serum-free Cell Culture the serum free media interactive online database

Bunton 2011 – The use of functional human tissues in drug development

Chailangkarn, Acab, Renato Muotri – 2012 – Modeling neurodevelopmental disorders using human neurons

Coleman – 2010 – A Human Approach to Drug Development Opportunities and Limitations

Coleman – 2014 – Human-based Systems in Drug and Chemical Safety Testing – Toward Replacement, the Single R

Coleman – Drug discovery and development tomorrow – changing the mindset

Coleman 2011 – Efficacy and safety of new medicines – a human focus

Coleman 2011 – Human Tissue in the Evaluation of Safety and Efficacy of New Medicines – A Viable Alternative to Animal Models

Colin and Lappin 2006 -The phase 0 microdosing concept

Collins et al 2008 -Transforming environmental health protection

Davis 2008 – A Prescription for Human Immunology

DesRochers et al 2013 – Bioengineered 3D Human Kidney Tissue – a Platform for the Determination of Nephrotoxicity

Edwards et al. – 2015 – Human tissue models for a human disease what are the barriers

Esch et al 2014 – How multi-organ microdevices can help foster drug development

Ferrario, Brustio, Hartung – 2014 – Glossary of reference terms for alternative test methods and their validation

Garcez et al 2016 – Zika virus impairs growth in human neurospheres and brain organoids

Gray et al 2016 – Animal antibodies – obsolete

Hartung – 2014 – 3D – A new dimension of in vitro research

Hartung 2007 – On validation

Hartung 2009 – toxicology for the 21 century

Hartung 2013 – From Alternative Methods to a New Regulatory Toxicology

Hartung 2016 – Making big sense from big data in toxicology by read-across

Hartung and McBride 2011 – On Mapping human toxome

Hartung et al 2009 – On education in alternative methods

Hartung et al 2010 – First alternative method validated by a retrospective weight-of-evidence approach

Hartung et al 2010 – Integrated testing strategies for safety assessments

Hartung et al. – 2010 – First alternative method validated by a retrospective weight-of-evidence approach to replace the Draize eye t

Harung and Leist 2008 -On the evolution of toxicology and the phasing out of animal testing

Heilker et al. – 2014 – iPS cell derived neuronal cells for drug discovery

Hennady et al 2012 – Human-Specific Histone Methylation Signatures at Transcription Start Sites in Prefrontal Neurons

Hillier and Bunton 2009 – Could Fresh Human Tissues Play a Key Role in Drug Development

Huang et al. 2016 Modelling the Tox21 10 K chemical profiles for in vivo toxicity prediction and mechanism characterization

Hudson 2008 – poster – A Case for the Replacement of Primates in Malaria Vaccine Research.pdf

Huh et al 2011 -From 3D cell culture to organs-on-chips

Imaizumi, Okano – 2014 – Modeling human neurological disorders with induced pluripotent stem cells

Khetani et al. – 2015 – Microengineered Liver Tissues for Drug Testing

Knight 2008 -Non-animal methodologies within biomedical research and toxicity testing

Krewski et al. – 2010 – Toxicity testing in the 21st century a vision and a strategy

Lancaster et al 2013 – Cerebral organoids model human brain development and microcephaly

Langley et al 2000- Volunteer studies replacing animal experiments in brain research

Leist et al 2008 – on the Real Success of 3R Approches

Leist et al. – 2012 – Novel technologies and an overall strategy to allow hazard assessment and risk prediction of chemicals, cosmeti

Leist et al. – 2014 – Consensus report on the future of animal-free systemic toxicity testing

Leslie et al. – 2011 – Aerosol Drug Delivery for Lung on a Chip

Li et al. – 2014 – embryonic stem cells-derived Rett Syndrome neurons

Marx et al 2016 – Biology-inspired Microphysiological System Approaches to Solve the Prediction Dilemma of Substance Testing

Materne et al. – 2015 – A multi-organ chip co-culture of neurospheres and liver equivalents for long-term substance testing

Moreno and Pearson 2013 – How can attrition rates be reduced in cancer drug discovery

Pamies, Hartung, Hogberg – 2014 – Biological and medical applications of a brain-on-a-chip

Punde et al. – 2014 – A biologically inspired lung-on-a-chip device for the study of protein-induced lung inflammation

Qian 2016 – Brain-Region-Specific Organoids Using Minibioreactors for Modeling ZIKV Exposure

Rice – 2011 – The Institutional Review Board is an Impediment to Human Research The Result is More Animal-Based Research

Rovida – 2010 – Food for thought … why no new in vitro tests will be done for REACH by registrants

Rovida et al. – 2015 – Integrated Testing Strategies ( ITS ) for Safety Assessment

Shakesheff, Rose – 2012 – Tissue engineering in the development of replacement technologies

Skommer, Wlodkowic – 2015 – Successes and future outlook for microfluidics-based cardiovascular drug discovery

Steffenhagen et al. 2011 – Identity, Fate and Potential of Cells Grown as Neurospheres – Species Matters

Stephen et al. 2013 Evidence-based Toxicology for the 21st century – opportunities and challenges

Sung et al 2013 – Microfabricated mammalian organ systems and their integration into models of whole animals and humans

Tukker , Groot et al 2016 – Is the time right for in vitro neurotoxicity testing using human iPSC-derived neurons

van de stolpe and Kauffmann 2015 – Innovative human specific investigational approaches to autoimmune disease

van der Meer and van den Berg 2012 – Organs-on-chips – breaking the in vitro impasse

van Vliet 2011 – Current Standing and Future Prospects for the Technologies Proposed to Transform Toxicity Testing in the 21st centur